Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Therapeutic effect of a combination of montelukast and vitamins A and D drops in children with bronchial asthma, and its influence on quality of life

Juan Zhang¹ , Junmin Zhang¹, Fengxia Shi¹, Wei Tian², Xiuzhen Liu¹

¹Pediatric ward 1; ²Department of Neurosurgery, Han Dan Central Hospital, Handan, China.

For correspondence:- Juan Zhang Email: zhangjuan9069@163.com

Accepted: 19 August 2021 Published: 30 September 2021

Citation: Zhang J, Zhang J, Shi F, Tian W, Liu X. Therapeutic effect of a combination of montelukast and vitamins A and D drops in children with bronchial asthma, and its influence on quality of life. Trop J Pharm Res 2021; 20(9):2005-2011 doi: 10.4314/tjpr.v20i9.30

© 2021 The authors.
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Abstract

Purpose: To investigate the efficacy of a combination of montelukast and vitamins A and D drops in bronchial asthma children, and its effect on quality of life.

Methods: Sixty bronchial asthma children from June 2018 to June 2020 were collected and randomized into study group and control group (30 cases in each group). Control group received montelukast sodium (chewable tablets), while the study group received vitamins A and D drops (capsules) plus. Clinical efficacy, lung function, serum inflammatory factors, and quality of life were evaluated and compared.

Results: Compared with control group, total treatment effectiveness was higher and the symptom remission period was shorter in the study group (p < 0.05). Post-treatment, the parameters of FEV1 and FVC increased in both groups, but higher in the study group (p < 0.05). Serum levels of CRP and IL-4 in both groups decreased after treatment, while serum IL-10 levels were significantly up-regulated. Compared with control group, the levels of these indicators were improved in the study group (p < 0.05). Post-treatment Chinese Version of Pediatric Quality of Life Asthma Specific Scale (PedSQL) score was higher than before treatment, with higher values (for all indicators) in the study group (p < 0.05).

Conclusion: The combination therapy of montelukast and vitamins A and D drops produces good clinical efficacy in children with bronchial asthma. It significantly shortens the time taken for relief of clinical symptoms, improves lung function, reduces inflammatory response, controls asthma, and improves the quality of life of the patients.

Keywords: Bronchial asthma, Vitamin A and D, Monteloust, Clinical effects